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NAD + and NMN restore oligodendrocyte differentiation in PA-treated cultures + Our recent findings demonstrated that PA can directly impair oligodendrocyte differentiation from neural stem cells or oligodendrocyte progenitors (Langley et al., 2019), and others have indicated that depletions in cellular NAD + can prevent differentiation of stem cells to mature oligodendrocytes (Stein & Imai, 2014)